All patients in Cohorts 1-4 will receive the combination treatment of PD-1 / PD-L1 checkpoint inhibitor plus N-803 for up to 17 cycles. Avelumab in combination with talazoparib will be investigated in patients with locally


Avelumab is an antibody that recognizes and attaches to a molecule called PD-L1. Validation of the MammaTyper® pathological complete response (pCR)-score as a predictor for response after neoadjuvant chemotherapy (NACT) in patients with early breast cancer (BC)Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Additionally, the investigators are looking to see if participants whose tumors contain a particular genetic make-up will have better response to Avelumab or the combination of Avelumab and Talazoparib. The primary objective of this study is to estimate the best objective response rate (CR or PR, ORR) in these patients within 24 weeks by RECIST 1.1 criteria. Please provide your last name. This phase II LUNG-MAP treatment trial studies how well combination treatment (talazoparib plus avelumab) works in treating patients with non-squamous non-small cell lung cancer that has an STK11 gene mutation and has come back (recurrent) or is stage IV.

resistant prostate cancer (CRPC).

Talazoparib is a potent, orally bioavailable PARP inhibitor with a dual mechanism (PARP enzyme inhibition and PARP trapping). J.T. DCC-3014 may help fight cancer by targeting a type of white blood cell called a macrophage. Though median overall survival did not differ between avelumab and … Palbociclib is a drug that may stop tumor cells from growing by blocking activity of two closely related enzymes (proteins that help chemical reactions in the body occur), called cyclin dependent kinases 4 and 6 (CDK 4 / 6) which are known to promote tumor cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This randomized pilot phase II trial studies how well fulvestrant with or without palbociclib and avelumab works in treating patients with hormone receptor positive, HER2 negative breast cancer that has spread to other parts of the body or that has come back after a period of improvement and cannot be removed by surgery, and have been previously treated with CDK and endocrine therapy. Endocrine therapy with fulvestrant prevents growth of hormone receptor positive breast cancer by blocking stimulation of tumor cells by estrogen. COVID-19 is an emerging, rapidly evolving situation. Using MultiOmyx™ to analyze correlations between immunosuppressive cells and tumor-infiltrating lymphocytes in the pancreatic tumor microenvironmentPoster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. This phase II trial studies the how well trastuzumab, vinorelbine tartrate, and avelumab with or without utomilumab work in treating patients with HER2-positive breast cancer that has spread to other parts of the body (metastatic).

This phase Ib trial studies the best dose of immunotherapy combinations with rituximab in treating patients with grade 1-3A follicular lymphoma that has come back (recurrent) or does not respond to treatment (refractory). In this research study, the investigators are looking to see whether Avelumab and Talazoparib are effective in treating recurrent and Metastatic Endometrial Cancer. DDR deficiency refers to a decrease in the ability of cells to respond to damaged DNA and to repair the damage, which can be caused by genetic mutations.

Vemurafenib in patients (pts) harboring BRAF V600 mutation. Vall d’Hebron Institute of Oncology (VHIO) Immuno-Oncology prognostic index (VIO): a new tool for improved patient (pt) selection in Phase 1 (Ph1) trials with Immune Checkpoint Inhibitors (ICI).Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Abstract The Dose Escalation Phase will determine the Maximum Tolerated Dose (MTD) and recommended Phase 2 dose (RP2D) of PT-112 in the combination as avelumab will be administered at a flat dose of 800 mg. JAVELIN PARP Medley (NCT03330405) is an open-label, multicohort, phase 1b/2 trial investigating avelumab plus talazoparib in ≈316 patients with selected solid tumors. Avelumab is an antibody that recognizes and attaches to a molecule called PD-L1. Galsky: Consultant, Advisory board: Merck, Pfizer, Merck-Serono, Genentech; Other research support: Merck, Bristol-Myers Squibb, Novartis. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving DCC-3014 and avelumab may help improve symptoms and shrink or stabilize cancer. Radiologic evaluation will occur at the end of each treatment cycle.

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