Available from http://www.ncbi.nlm.nih.gov/books/NBK1311/ Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A. TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. 2015 May;134(5):497-507. doi: 10.1007/s00439-014-1470-0. A pathway-based genotyping analysis suggested rs2078486 was a novel TP53 SNP, but very few studies replicate this association.TP53 rs1042522 is the most commonly studied SNP, but very few studies examined its potential interaction with environmental factors in relation to lung cancer risk. Small cell lung cancers nearly always have TP53 gene mutations; however, these mutations may also occur in non-small cell lung cancer. Such cells may continue to divide in an uncontrolled way, leading to the growth of tumors.Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Clin Cancer Res. Epub 2012 Mar 4.

In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. Epub 2012 Mar 4. ©2014 AACR . Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells. Review. 2018 Aug 9;174(4):1033. doi: 10.1016/j.cell.2018.07.036. Cold Spring Harb Perspect Biol. 2015;2015:341723. doi: 10.1155/2015/341723. J Med Genet. If the DNA can be repaired, p53 activates other genes to fix the damage. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). Seattle (WA): University of Washington, Seattle; 1993-2017. Merino D, Malkin D. p53 and hereditary cancer. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ; TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP. doi: 10.1101/cshperspect.a001008. 2010 Jan;2(1):a001008.
By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.Because p53 is essential for regulating DNA repair and cell division, it has been nicknamed the "guardian of the genome. A few different gene mutations help non-small cell lung cancers (NSCLCs) spread and grow. TP53, the most frequently mutated gene in human cancer, encodes the p53 DNA-binding transcription factor that, in turn, regulates multiple DNA repair genes and several hallmark processes of cancer, the researchers said.TP53 has historically been considered a tumor suppressor gene that promotes cancer when it loses this function through mutation.

Users with questions about a personal health condition should consult with a Cancer Genome Atlas Research Network. TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes.
The results of this comprehensive study show both microbiome-gene and microbiome-exposure interactions in squamous cell carcinoma lung cancer tissue. 2018 Aug 9;174(4):1033. doi: 10.1016/j.cell.2018.07.036. If the DNA can be repaired, p53 activates other genes to fix the damage. Human lung cancers are classified into two major types, small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). Masica DL, Li S, Douville C, Manola J, Ferris RL, Burtness B, Forastiere AA, Koch WM, Chung CH, Karchin R. Predicting survival in head and neck squamous cell carcinoma from TP53 mutation. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. Cell. Epub 2014 Jun 15.

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